Fermentation And Up Stream Processing:

  • Mini and midi amplifications in host (non-GMP)
  • Small scale fermentation in bioreactor (GMP-like or GMP)
  • Large scale fermentation in bioreactor (GMP-like or GMP)
  • Up Stream processing:

    Growth media
    Biomass
    Inoculation density
    Dissolved oxygen
    Sparge rate and stir rate
    Temperature
    Culture time
    Filtration

  • In-process analytics